CLDN7

Across TCGA cell cohorts, CLDN7 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,176 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CLDN7-associated GO terms across cancer lineages are Positive regulation of iron ion transport, Positive regulation of iron ion transmembrane transport, and Calcium-independent cell-cell adhesion. Each is linked with CLDN7 in more than 13 cancer types. Because this analysis shows association rather than direction, both CLDN7-to-partner and partner-to-CLDN7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of iron ion transport grouped by CLDN7-low versus CLDN7-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN7→partner) and Y-score (partner→CLDN7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Positive regulation of iron ion transport →	+1.828	+3.478	<.001	<.001	3	14
STOMACH	Positive regulation of iron ion transmembrane transport →	+1.828	+3.478	<.001	<.001	3	14
LUNG_SCLC	Calcium-independent cell-cell adhesion →	+0.597	+4.298	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Maintenance of blood-brain barrier →	+0.214	+3.800	.004	<.001	3	13
URINARY_TRACT	Response to mycotoxin →	+1.505	+5.246	<.001	<.001	3	11
PANCREAS	Regulation of mitochondrion organization →	+0.081	+3.390	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,176 associations by consensus.

Positive regulation of iron ion transport by CLDN7 expression — STOMACH

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