Across TCGA patient cohorts, CLDN6 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,026 significant associations in total. THCA shows the largest number of these associations.

The most reproducible CLDN6-associated GO terms across cancer lineages are Establishment of spindle orientation, Non-canonical Wnt signaling pathway, and Establishment of mitotic spindle localization. Each is linked with CLDN6 in more than 16 cancer types. Because this analysis shows association rather than direction, both CLDN6-to-partner and partner-to-CLDN6 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN6→partner) and Y-score (partner→CLDN6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
MESO	Establishment of spindle orientation →	+0.052	+1.094	<.001	<.001	3	17
MESO	Non-canonical Wnt signaling pathway →	+0.032	+0.832	.003	.001	2	16
TGCT	Establishment of mitotic spindle localization →	+0.056	+1.011	<.001	<.001	3	15
STAD	Positive regulation of telomerase RNA localization to Cajal body →	+0.049	+1.192	<.001	<.001	3	14
STAD	Transcription by RNA polymerase I →	+0.035	+0.792	<.001	<.001	3	14
ACC	G2/MI transition of meiotic cell cycle →	+0.093	+0.181	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,026 associations by consensus.

Exploration

CLDN6 survival (RNA) · tumor vs normal (RNA) · all CLDN6 data types