Across TCGA patient cohorts, CLDN6 mutation is significantly associated with the RNA expression of many other genes, with 141 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible CLDN6-associated genes across cancer lineages are BANF1P5, RNU5A-5P, and MIR8062. Each is linked with CLDN6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN6-to-partner and partner-to-CLDN6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN6→partner) and Y-score (partner→CLDN6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BANF1P5 →	+0.209	+2.838	.008	.003	3	2
LUSC	RNU5A-5P →	+0.606	+5.038	<.001	.009	3	2
BRCA	MIR8062 →	+0.387	+7.471	<.001	.008	3	1
COAD	RNU6-1119P →	+0.397	+6.142	<.001	<.001	3	1
COAD	SNORD116-12 →	+0.418	+4.602	<.001	.008	3	1
COAD	MIR548A3 →	+0.572	+5.221	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 141 associations by consensus.

Exploration

CLDN6 survival (RNA) · tumor vs normal (RNA) · all CLDN6 data types