Across TCGA cell cohorts, CLDN6 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLDN6-associated genes across cancer lineages are GRM6, COX6A2, and OR1K1. Each is linked with CLDN6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN6-to-partner and partner-to-CLDN6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN6→partner) and Y-score (partner→CLDN6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GRM6 →	+0.109	+3.793	<.001	.007	3	1
LARGE_INTESTINE	COX6A2 →	+0.082	+4.437	<.001	.004	3	1
LARGE_INTESTINE	OR1K1 →	+0.051	+3.747	<.001	.008	3	1
LARGE_INTESTINE	VWC2L →	+0.011	+3.930	<.001	.003	3	1
LARGE_INTESTINE	PROP1 →	+0.026	+4.054	<.001	.004	3	1
LARGE_INTESTINE	OR2V2 →	+0.022	+4.510	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

CLDN6 survival (RNA) · tumor vs normal (RNA) · all CLDN6 data types