Across TCGA patient cohorts, CLDN5 protein abundance is significantly associated with the RNA expression of many other genes, with 2,094 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CLDN5-associated genes across cancer lineages are SLC39A14, FKBP1B, and COX4I2. Each is linked with CLDN5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN5-to-partner and partner-to-CLDN5 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN5→partner) and Y-score (partner→CLDN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SLC39A14 →	+0.586	+0.653	.004	.003	3	2
BRCA	FKBP1B →	+1.312	+1.392	.005	.008	3	2
BRCA	COX4I2 →	+1.062	+1.050	.003	.001	3	2
LSCC	EXOC6 →	+0.514	+0.563	.001	<.001	3	2
LUAD	CILP →	-1.492	-0.614	.001	.003	3	2
HNSC	PDE2A →	+0.869	+0.640	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,094 associations by consensus.

Exploration

CLDN5 survival (RNA) · tumor vs normal (RNA) · all CLDN5 data types