Across TCGA cell cohorts, CLDN5 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,786 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CLDN5-associated GO terms across cancer lineages are Leading strand elongation, Cell cycle phase transition, and Nucleosome assembly. Each is linked with CLDN5 in more than 11 cancer types. Because this analysis shows association rather than direction, both CLDN5-to-partner and partner-to-CLDN5 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN5→partner) and Y-score (partner→CLDN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Leading strand elongation →	+0.197	+0.696	<.001	.002	2	12
BONE	Cell cycle phase transition →	+0.084	+1.023	<.001	<.001	3	9
BONE	Nucleosome assembly →	+0.133	+0.902	<.001	.001	3	8
BONE	Nucleosome organization →	+0.102	+1.231	<.001	.002	3	7
BLOOD_Lymphoma	Mitotic DNA integrity checkpoint signaling →	+0.051	+0.139	<.001	.005	2	8
KIDNEY	Regulation of nuclear cell cycle DNA replication →	+0.110	+0.053	<.001	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,786 associations by consensus.

Exploration

CLDN5 survival (RNA) · tumor vs normal (RNA) · all CLDN5 data types