Across TCGA cell cohorts, CLDN5 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLDN5-associated genes across cancer lineages are KRTAP17-1, DAZL, and MYF6. Each is linked with CLDN5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN5-to-partner and partner-to-CLDN5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN5→partner) and Y-score (partner→CLDN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	KRTAP17-1 →	+0.032	+5.228	<.001	.005	3	1
STOMACH	DAZL →	+0.027	+4.129	.005	.007	3	1
LARGE_INTESTINE	MYF6 →	+0.014	+4.415	<.001	.007	3	1
LARGE_INTESTINE	OR1L6 →	+0.027	+5.022	<.001	.002	3	1
LARGE_INTESTINE	OR2B3 →	+0.017	+4.415	<.001	.007	3	1
LARGE_INTESTINE	CELA2B →	+0.084	+4.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

CLDN5 survival (RNA) · tumor vs normal (RNA) · all CLDN5 data types