Across TCGA pan-cancer cohorts, CLDN4 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated CLDN4 data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CLDN4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CLDN4 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC and LUAD are the cancer types where CLDN4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	1.000	0.262	<.001	22	view →
LUAD	DFS	Median	II,III,IV	0.165	0.866	.002	13	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: CLDN4 tumor-vs-normal RNA expression · all CLDN4 data types