Across TCGA patient cohorts, CLDN4 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,156 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible CLDN4-associated proteins across cancer lineages are PEX1, MACC1, and BAIAP2L1. Each is linked with CLDN4 in more than 4 cancer types. Because this analysis shows association rather than direction, both CLDN4-to-partner and partner-to-CLDN4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN4→partner) and Y-score (partner→CLDN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PEX1 →	+0.371	+1.614	<.001	<.001	3	5
OV	MACC1 →	+0.893	+0.742	<.001	.001	3	5
LSCC	BAIAP2L1 →	+0.715	+1.194	<.001	<.001	3	5
LSCC	CDH1 →	+0.529	+0.940	<.001	<.001	3	5
LSCC	ESRP2 →	+0.535	+1.045	<.001	<.001	3	5
HNSC	PARD6B →	+0.491	+1.468	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,156 associations by consensus.

Exploration

CLDN4 survival (RNA) · tumor vs normal (RNA) · all CLDN4 data types