Across TCGA patient cohorts, CLDN4 protein abundance is significantly associated with the RNA expression of many other genes, with 4,543 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CLDN4-associated genes across cancer lineages are TRAV12-1, BAIAP2L1, and SP140. Each is linked with CLDN4 in more than 2 cancer types. Because this analysis shows association rather than direction, both CLDN4-to-partner and partner-to-CLDN4 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN4→partner) and Y-score (partner→CLDN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TRAV12-1 →	-0.935	-0.730	.001	<.001	3	3
LSCC	BAIAP2L1 →	+0.865	+0.716	<.001	.001	3	3
LSCC	SP140 →	-1.002	-0.735	<.001	<.001	3	3
HNSC	MIR4652 →	+2.022	+0.603	<.001	.002	3	3
OV	MTMR9 →	-0.614	-0.706	.001	.006	3	2
COAD	BLZF1 →	-0.492	-0.640	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,543 associations by consensus.

Exploration

CLDN4 survival (RNA) · tumor vs normal (RNA) · all CLDN4 data types