CLDN4

RNA expression — cross-omics
Cross-omicsRNA → FUNCTION-RNACell-linePairwise association · TCGA cohorts

Across TCGA cell cohorts, CLDN4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,943 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CLDN4-associated GO terms across cancer lineages are Paracellular transport, Calcium-independent cell-cell adhesion, and Response to progesterone. Each is linked with CLDN4 in more than 14 cancer types. Because this analysis shows association rather than direction, both CLDN4-to-partner and partner-to-CLDN4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN4→partner) and Y-score (partner→CLDN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner GO termX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUNG_NSCLC_LUSCParacellular transport →+1.671+5.804<.001<.001315
LUNG_SCLCCalcium-independent cell-cell adhesion →+0.436+3.238<.001<.001313
UPPER_AERODIGESTIVE_TRACTResponse to progesterone →+0.166+2.801<.001<.001313
URINARY_TRACTPositive regulation of potassium ion import across plasma membrane →+0.230+3.904<.001.001312
KIDNEYMammary gland development →+0.151+4.055<.001<.001312
LUNG_SCLCSensory perception of salty taste →+1.365+3.354<.001<.001312
Each partner links to its Q-omics profile. Showing the 6 strongest of 4,943 associations by consensus.

Exploration