CLDN34

Across TCGA cell cohorts, CLDN34 RNA expression is significantly associated with the go_rna of many other GO terms, with 908 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CLDN34-associated GO terms across cancer lineages are Regulation of protein localization to nucleus, Assembly of actomyosin apparatus involved in cytokinesis, and Actomyosin contractile ring assembly. Each is linked with CLDN34 in more than 4 cancer types. Because this analysis shows association rather than direction, both CLDN34-to-partner and partner-to-CLDN34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein localization to nucleus grouped by CLDN34-low versus CLDN34-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN34→partner) and Y-score (partner→CLDN34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of protein localization to nucleus →	+0.083	+0.028	<.001	.001	3	5
SKIN	Assembly of actomyosin apparatus involved in cytokinesis →	+0.099	+0.129	<.001	.001	3	4
SKIN	Actomyosin contractile ring assembly →	+0.099	+0.129	<.001	.001	3	4
KIDNEY	Epidermis development →	+0.063	+0.018	<.001	.004	3	4
LARGE_INTESTINE	Negative regulation of response to food →	-0.097	-0.049	.004	.004	3	3
LARGE_INTESTINE	Negative regulation of appetite →	-0.097	-0.049	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 908 associations by consensus.

Regulation of protein localization to nucleus by CLDN34 expression — KIDNEY

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