Across TCGA patient cohorts, CLDN25 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,406 significant associations in total. STAD shows the largest number of these associations.

The most reproducible CLDN25-associated GO terms across cancer lineages are Regulation of membrane permeability, U2-type prespliceosome assembly, and Nucleoside triphosphate metabolic process. Each is linked with CLDN25 in more than 7 cancer types. Because this analysis shows association rather than direction, both CLDN25-to-partner and partner-to-CLDN25 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN25→partner) and Y-score (partner→CLDN25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of membrane permeability →	+0.108	+0.063	<.001	<.001	3	8
STAD	U2-type prespliceosome assembly →	+0.122	+0.088	<.001	<.001	3	8
STAD	Nucleoside triphosphate metabolic process →	+0.107	+0.059	<.001	<.001	3	8
STAD	Obsolete positive regulation of mitochondrion organization →	+0.096	+0.064	<.001	<.001	3	8
STAD	Peptidyl-lysine methylation →	+0.082	+0.071	<.001	<.001	3	8
STAD	Protein transmembrane transport →	+0.097	+0.060	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,406 associations by consensus.

Exploration

CLDN25 survival (RNA) · tumor vs normal (RNA) · all CLDN25 data types