Across TCGA patient cohorts, CLDN25 mutation is significantly associated with the RNA expression of many other genes, with 1,074 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLDN25-associated genes across cancer lineages are RNU6-800P, VPS26B, and C18orf32. Each is linked with CLDN25 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN25-to-partner and partner-to-CLDN25 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN25→partner) and Y-score (partner→CLDN25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RNU6-800P →	+0.466	+5.039	<.001	.008	3	2
UCEC	VPS26B →	+0.479	+3.353	.003	.005	3	2
UCEC	C18orf32 →	+0.388	+3.210	.004	.009	3	2
UCEC	ARVCF →	+0.752	+3.617	<.001	.001	3	2
UCEC	LIAS →	+0.519	+3.700	.001	.001	3	2
LUAD	RNU6-1074P →	+0.382	+5.584	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,074 associations by consensus.

Exploration

CLDN25 survival (RNA) · tumor vs normal (RNA) · all CLDN25 data types