Across TCGA patient cohorts, CLDN25 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLDN25-associated genes across cancer lineages are XBP1, Caspase-8, and p62 Lck ligand. Each is linked with CLDN25 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN25-to-partner and partner-to-CLDN25 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN25→partner) and Y-score (partner→CLDN25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	XBP1 →	-0.292	-2.986	<.001	.035	3	1
UCEC	Caspase-8 →	-0.278	-2.973	.035	.035	3	1
UCEC	p62 Lck ligand →	+0.467	+3.321	.006	.010	2	1
UCEC	VEGFR2 →	+0.309	+3.335	.047	.005	2	1
UCEC	Annexin-1 →	+0.880	+3.321	.001	.010	1	1
UCEC	Tuberin →	+0.453	+3.321	.001	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

CLDN25 survival (RNA) · tumor vs normal (RNA) · all CLDN25 data types