Across TCGA cell cohorts, CLDN25 RNA expression is significantly associated with the go_rna of many other GO terms, with 457 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible CLDN25-associated GO terms across cancer lineages are Negative regulation of T-helper cell differentiation, Pyrimidine nucleoside catabolic process, and Isopentenyl diphosphate metabolic process. Each is linked with CLDN25 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN25-to-partner and partner-to-CLDN25 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN25→partner) and Y-score (partner→CLDN25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of T-helper cell differentiation →	-0.090	-0.078	.003	.007	3	2
BREAST	Pyrimidine nucleoside catabolic process →	-1.148	-0.050	<.001	.002	3	2
BREAST	Isopentenyl diphosphate metabolic process →	+0.121	+0.044	.003	.006	3	2
BONE	Intracellular copper ion homeostasis →	-0.099	-0.041	.009	.009	3	2
BREAST	Regulation of thrombin-activated receptor signaling pathway →	-0.989	-0.065	.001	.004	3	2
BREAST	Negative regulation of thrombin-activated receptor signaling pathway →	-0.989	-0.065	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 457 associations by consensus.

Exploration

CLDN25 survival (RNA) · tumor vs normal (RNA) · all CLDN25 data types