CLDN22

Across TCGA patient cohorts, CLDN22 RNA expression is significantly associated with the mutation status of many other genes, with 17 significant associations in total. SCLC shows the largest number of these associations.

The most reproducible CLDN22-associated genes across cancer lineages are PLCB4, SIGLEC5, and C5. Each is linked with CLDN22 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN22-to-partner and partner-to-CLDN22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLCB4 grouped by CLDN22-low versus CLDN22-high in SCLC.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN22→partner) and Y-score (partner→CLDN22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	PLCB4 →	+4.847	+1.173	.009	.004	3	1
SCLC	SIGLEC5 →	+4.847	+1.173	.009	.004	3	1
SCLC	C5 →	+4.847	+1.261	.009	.002	3	1
SCLC	CACNG6 →	+4.847	+2.300	.009	<.001	3	1
SCLC	SNX14 →	+5.432	+1.734	<.001	<.001	3	1
SCLC	MYLK4 →	+4.847	+1.261	.009	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

PLCB4 by CLDN22 expression — SCLC

Explore this box plot interactively →