CLDN22

Across TCGA patient cohorts, CLDN22 mutation is significantly associated with the RNA expression of many other genes, with 1,161 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLDN22-associated genes across cancer lineages are SURF6P1, RN7SL722P, and ELAVL4-AS1. Each is linked with CLDN22 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN22-to-partner and partner-to-CLDN22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SURF6P1 grouped by CLDN22-low versus CLDN22-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN22→partner) and Y-score (partner→CLDN22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SURF6P1 →	+0.059	+8.055	<.001	.007	3	2
BRCA	RN7SL722P →	+0.164	+8.471	<.001	.005	3	1
CESC	ELAVL4-AS1 →	+0.051	+5.103	.006	.008	3	1
CESC	RNU7-173P →	+0.610	+5.969	<.001	.002	3	1
CESC	RN7SL447P →	+0.230	+5.201	<.001	.007	3	1
CESC	TMEM248P1 →	+0.039	+6.837	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,161 associations by consensus.

SURF6P1 by CLDN22 expression — BRCA

Explore this box plot interactively →