CLDN22

Across TCGA patient cohorts, CLDN22 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLDN22-associated genes across cancer lineages are eEF2, EGFR_pY1068, and INPP4B. Each is linked with CLDN22 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN22-to-partner and partner-to-CLDN22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by CLDN22-low versus CLDN22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN22→partner) and Y-score (partner→CLDN22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.509	+2.321	.004	.035	3	1
UCEC	EGFR_pY1068 →	-0.273	-3.321	.030	.010	3	1
UCEC	INPP4B →	-0.427	-3.446	.008	.005	3	1
UCEC	mTOR_pS2448 →	-0.240	-3.459	.001	.005	3	1
UCEC	Notch1 →	+0.180	+2.817	.010	.036	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.615	-3.169	.006	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

eEF2 by CLDN22 expression — UCEC

Explore this box plot interactively →