CLDN22

Across TCGA cell cohorts, CLDN22 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,339 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CLDN22-associated GO terms across cancer lineages are Regulation of microtubule nucleation, Alkaloid metabolic process, and Negative regulation of T-helper 17 cell differentiation. Each is linked with CLDN22 in more than 4 cancer types. Because this analysis shows association rather than direction, both CLDN22-to-partner and partner-to-CLDN22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of microtubule nucleation grouped by CLDN22-low versus CLDN22-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN22→partner) and Y-score (partner→CLDN22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Regulation of microtubule nucleation →	+0.094	+1.067	<.001	.005	3	5
LIVER	Alkaloid metabolic process →	-0.106	-0.298	.003	.003	3	5
BLOOD_Leukemia	Negative regulation of T-helper 17 cell differentiation →	+0.074	+0.086	<.001	.002	3	5
BLOOD_Lymphoma	Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway →	+0.120	+0.550	<.001	.008	3	4
BLOOD_Lymphoma	Regulation of collagen metabolic process →	+0.096	+0.542	<.001	.009	3	4
BLOOD_Lymphoma	Negative regulation of T-helper 17 cell lineage commitment →	+0.218	+0.553	.002	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,339 associations by consensus.

Regulation of microtubule nucleation by CLDN22 expression — BLOOD_Lymphoma

Explore this box plot interactively →