CLDN20

Across TCGA patient cohorts, CLDN20 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,824 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CLDN20-associated proteins across cancer lineages are SF3B3, GTF3C1, and HDAC2. Each is linked with CLDN20 in more than 4 cancer types. Because this analysis shows association rather than direction, both CLDN20-to-partner and partner-to-CLDN20 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLDN20 versus SF3B3 in LSCC, with a Pearson correlation of 0.34.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN20→partner) and Y-score (partner→CLDN20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SF3B3 →	+0.165	+0.571	<.001	<.001	3	5
GBM	GTF3C1 →	+0.234	+0.451	.001	.001	3	5
LSCC	HDAC2 →	+0.289	+0.837	<.001	<.001	3	5
LSCC	ZMYM3_S464 →	+0.505	+0.897	<.001	<.001	3	4
LSCC	ZNF326 →	+0.393	+0.868	<.001	<.001	3	4
LSCC	SMU1 →	+0.168	+0.618	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,824 associations by consensus.

CLDN20 vs SF3B3 — LSCC

Explore this scatter interactively →