CLDN20

Across TCGA cell cohorts, CLDN20 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,499 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CLDN20-associated GO terms across cancer lineages are Microtubule nucleation, Nuclear export, and Microtubule polymerization. Each is linked with CLDN20 in more than 16 cancer types. Because this analysis shows association rather than direction, both CLDN20-to-partner and partner-to-CLDN20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Microtubule nucleation grouped by CLDN20-low versus CLDN20-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN20→partner) and Y-score (partner→CLDN20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Microtubule nucleation →	+0.167	+0.369	<.001	<.001	3	17
BONE	Nuclear export →	+0.083	+0.286	<.001	.002	3	16
BONE	Microtubule polymerization →	+0.107	+0.306	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Termination of RNA polymerase II transcription →	+0.109	+0.349	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	mRNA splice site recognition →	+0.130	+0.277	<.001	<.001	3	13
BLOOD_Lymphoma	Positive regulation of mRNA catabolic process →	+0.068	+0.343	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,499 associations by consensus.

Microtubule nucleation by CLDN20 expression — BONE

Explore this box plot interactively →