CLDN20

Across TCGA cell cohorts, CLDN20 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLDN20-associated genes across cancer lineages are OR6Q1, TBC1D21, and FAM153B. Each is linked with CLDN20 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN20-to-partner and partner-to-CLDN20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6Q1 grouped by CLDN20-low versus CLDN20-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN20→partner) and Y-score (partner→CLDN20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR6Q1 →	+0.012	+3.700	<.001	.009	3	2
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	FAM153B →	+0.599	+4.011	<.001	.001	3	1
LARGE_INTESTINE	ADORA3 →	+0.039	+3.584	.006	.006	3	1
LARGE_INTESTINE	XCR1 →	+0.299	+3.491	<.001	.006	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

OR6Q1 by CLDN20 expression — LARGE_INTESTINE

Explore this box plot interactively →