CLDN2

Across TCGA patient cohorts, CLDN2 protein abundance is significantly associated with the RNA expression of many other genes, with 2,027 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible CLDN2-associated genes across cancer lineages are CCM2, RGS20, and C11orf45. Each is linked with CLDN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN2-to-partner and partner-to-CLDN2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLDN2 versus CCM2 in PDAC, with a Pearson correlation of -0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN2→partner) and Y-score (partner→CLDN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CCM2 →	-0.266	-1.222	.002	.006	3	2
CCRCC	RGS20 →	-0.549	-0.547	.002	<.001	3	2
CCRCC	C11orf45 →	-0.418	-0.456	<.001	<.001	3	2
PDAC	MRPS36P3 →	-0.547	-1.244	.004	<.001	3	2
PDAC	LRRC37A17P →	-0.136	-1.006	<.001	.002	3	2
COAD	ACY3 →	+1.300	+1.488	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,027 associations by consensus.

CLDN2 vs CCM2 — PDAC

Explore this scatter interactively →