CLDN2

Across TCGA patient cohorts, CLDN2 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLDN2-associated genes across cancer lineages are 14-3-3_beta, eIF4E, and A-Raf_pS299. Each is linked with CLDN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN2-to-partner and partner-to-CLDN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by CLDN2-low versus CLDN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN2→partner) and Y-score (partner→CLDN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.085	-1.847	.018	.049	3	1
UCEC	eIF4E →	+0.184	+2.335	.015	.018	3	1
UCEC	A-Raf_pS299 →	-0.085	-2.115	.049	.017	3	1
UCEC	p62 Lck ligand →	+0.325	+2.321	.005	.001	3	1
UCEC	PCNA →	+0.221	+3.584	.004	.002	3	1
UCEC	Annexin-1 →	+0.603	+2.242	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

14-3-3_beta by CLDN2 expression — UCEC

Explore this box plot interactively →