CLDN19

Across TCGA patient cohorts, CLDN19 protein abundance is significantly associated with the go_rna of many other GO terms, with 144 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible CLDN19-associated GO terms across cancer lineages are Endolysosomal toll-like receptor signaling pathway, Regulation of skeletal muscle satellite cell proliferation, and Aminophospholipid transport. Each is linked with CLDN19 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN19-to-partner and partner-to-CLDN19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endolysosomal toll-like receptor signaling pathway grouped by CLDN19-low versus CLDN19-high in CCRCC.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN19→partner) and Y-score (partner→CLDN19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	Endolysosomal toll-like receptor signaling pathway →	-0.081	-0.452	.005	.001	3	1
CCRCC	Regulation of skeletal muscle satellite cell proliferation →	-0.125	-0.452	<.001	.001	3	1
CCRCC	Aminophospholipid transport →	-0.170	-0.509	.001	.006	3	1
CCRCC	Regulation of calcium ion-dependent exocytosis →	+0.083	+0.478	.001	<.001	3	1
CCRCC	Peptidyl-lysine modification →	-0.040	-0.491	.002	.002	3	1
CCRCC	Acetate ester metabolic process →	+0.170	+0.464	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 144 associations by consensus.

Endolysosomal toll-like receptor signaling pathway by CLDN19 expression — CCRCC

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