CLDN19

Across TCGA patient cohorts, CLDN19 mutation is significantly associated with the RNA expression of many other genes, with 743 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLDN19-associated genes across cancer lineages are RN7SL291P, LINC02539, and GFI1. Each is linked with CLDN19 in more than 2 cancer types. Because this analysis shows association rather than direction, both CLDN19-to-partner and partner-to-CLDN19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL291P grouped by CLDN19-low versus CLDN19-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN19→partner) and Y-score (partner→CLDN19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL291P →	+0.089	+3.943	<.001	.002	3	3
COAD	LINC02539 →	+0.346	+3.832	<.001	.003	3	2
UCEC	GFI1 →	+0.702	+3.928	<.001	<.001	3	2
UCEC	CLEC12A →	+0.430	+2.201	.002	.009	3	2
UCEC	LPXN →	+0.636	+2.818	<.001	.001	3	2
UCEC	NEUROG3 →	+0.525	+2.824	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 743 associations by consensus.

RN7SL291P by CLDN19 expression — SKCM

Explore this box plot interactively →