CLDN19

Across TCGA patient cohorts, CLDN19 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLDN19-associated genes across cancer lineages are MEK1, ATM, and eIF4E. Each is linked with CLDN19 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN19-to-partner and partner-to-CLDN19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by CLDN19-low versus CLDN19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN19→partner) and Y-score (partner→CLDN19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.516	+3.584	.001	.002	3	2
UCEC	ATM →	-0.488	-2.000	.016	.032	3	2
UCEC	eIF4E →	+0.265	+2.700	.005	.006	3	1
UCEC	Fibronectin →	-0.380	-3.449	.010	.005	3	1
UCEC	IGFBP2 →	-0.876	-2.700	.002	.006	3	1
UCEC	p27_pT198 →	+0.151	+3.807	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

MEK1 by CLDN19 expression — UCEC

Explore this box plot interactively →