CLDN17

Across TCGA patient cohorts, CLDN17 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,715 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible CLDN17-associated GO terms across cancer lineages are Skin epidermis development, Regulation of epidermis development, and Epidermal cell differentiation. Each is linked with CLDN17 in more than 10 cancer types. Because this analysis shows association rather than direction, both CLDN17-to-partner and partner-to-CLDN17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Skin epidermis development grouped by CLDN17-low versus CLDN17-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN17→partner) and Y-score (partner→CLDN17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Skin epidermis development →	+0.076	+0.188	<.001	.001	3	11
STAD	Regulation of epidermis development →	+0.078	+0.132	<.001	<.001	3	9
ESCA	Epidermal cell differentiation →	+0.083	+1.280	<.001	<.001	3	9
STAD	Endosomal lumen acidification →	+0.088	+0.138	<.001	<.001	3	9
ESCA	Regulation of defense response to bacterium →	+0.063	+0.878	<.001	<.001	3	8
ESCA	Negative regulation of defense response to bacterium →	+0.082	+0.948	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,715 associations by consensus.

Skin epidermis development by CLDN17 expression — STAD

Explore this box plot interactively →