CLDN17

Across TCGA cell cohorts, CLDN17 RNA expression is significantly associated with the mutation status of many other genes, with 106 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLDN17-associated genes across cancer lineages are KRT6B, EGFR, and TEX15. Each is linked with CLDN17 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN17-to-partner and partner-to-CLDN17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT6B grouped by CLDN17-low versus CLDN17-high in LARGE_INTESTINE.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN17→partner) and Y-score (partner→CLDN17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KRT6B →	+3.345	+0.051	.007	<.001	3	2
LARGE_INTESTINE	EGFR →	+2.345	+0.035	.007	.001	3	2
OESOPHAGUS	TEX15 →	+3.392	+0.409	.007	<.001	3	1
OESOPHAGUS	NLRP9 →	+3.392	+0.407	.007	<.001	3	1
LIVER	ARHGEF26 →	+3.977	+0.021	.006	<.001	3	1
LIVER	NCOR1 →	+3.977	+0.021	.006	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 106 associations by consensus.

KRT6B by CLDN17 expression — LARGE_INTESTINE

Explore this box plot interactively →