CLDN17

Across TCGA cell cohorts, CLDN17 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLDN17-associated genes across cancer lineages are FTHL17, IFNA16, and OR52A5. Each is linked with CLDN17 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN17-to-partner and partner-to-CLDN17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FTHL17 grouped by CLDN17-low versus CLDN17-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN17→partner) and Y-score (partner→CLDN17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FTHL17 →	+0.081	+5.415	<.001	.004	3	1
LARGE_INTESTINE	IFNA16 →	+0.032	+5.415	<.001	.004	3	1
LARGE_INTESTINE	OR52A5 →	+0.006	+6.022	<.001	.001	3	1
LARGE_INTESTINE	NPAP1 →	+0.006	+6.022	<.001	.001	3	1
LARGE_INTESTINE	LCE4A →	+0.093	+6.022	<.001	.001	3	1
LARGE_INTESTINE	OR2J1 →	+0.006	+6.022	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

FTHL17 by CLDN17 expression — LARGE_INTESTINE

Explore this box plot interactively →