CLDN16

Across TCGA patient cohorts, CLDN16 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,312 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLDN16-associated proteins across cancer lineages are PRPSAP2, RALGAPA1, and CLDN1. Each is linked with CLDN16 in more than 3 cancer types. Because this analysis shows association rather than direction, both CLDN16-to-partner and partner-to-CLDN16 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLDN16 versus PRPSAP2 in UCEC, with a Pearson correlation of -0.34.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN16→partner) and Y-score (partner→CLDN16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRPSAP2 →	-0.307	-1.539	<.001	.001	3	4
BRCA	RALGAPA1 →	-0.238	-0.240	<.001	.002	3	4
LSCC	CLDN1 →	+1.206	+1.610	<.001	<.001	3	4
BRCA	S100B →	+1.247	+0.509	<.001	<.001	3	3
LUAD	AHDC1_S1476 →	+0.298	+0.361	.003	.005	3	3
LUAD	EPB41L1 →	+0.557	+0.609	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,312 associations by consensus.

CLDN16 vs PRPSAP2 — UCEC

Explore this scatter interactively →