CLDN16

Across TCGA patient cohorts, CLDN16 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLDN16-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, MEK1, and p62 Lck ligand. Each is linked with CLDN16 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN16-to-partner and partner-to-CLDN16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by CLDN16-low versus CLDN16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN16→partner) and Y-score (partner→CLDN16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.644	+3.009	.008	.019	3	2
UCEC	MEK1 →	+0.352	+3.000	.046	.036	3	1
UCEC	p62 Lck ligand →	+0.347	+3.179	.027	.010	2	1
SKCM	IGFBP2 →	-0.710	-3.169	.010	.019	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Acetyl-a-Tubulin-Lys40 by CLDN16 expression — UCEC

Explore this box plot interactively →