CLDN16

Across TCGA cell cohorts, CLDN16 RNA expression is significantly associated with the RNA expression of many other genes, with 4,680 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible CLDN16-associated genes across cancer lineages are CLDN1, LCN2, and NUAK2. Each is linked with CLDN16 in more than 15 cancer types. Because this analysis shows association rather than direction, both CLDN16-to-partner and partner-to-CLDN16 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLDN16 versus CLDN1 in LIVER, with a Pearson correlation of 0.67.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN16→partner) and Y-score (partner→CLDN16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CLDN1 →	+6.092	+1.190	<.001	.001	3	16
LUNG_NSCLC_LUSC	LCN2 →	+4.845	+1.021	.004	.002	2	6
OVARY	NUAK2 →	+1.821	+3.698	<.001	<.001	3	5
OVARY	GRB7 →	+2.586	+3.923	<.001	<.001	2	5
OVARY	ZBED2 →	+3.147	+4.020	<.001	<.001	3	4
OESOPHAGUS	TMEM265 →	+2.419	+1.098	<.001	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,680 associations by consensus.

CLDN16 vs CLDN1 — LIVER

Explore this scatter interactively →