CLDN16

Across TCGA cell cohorts, CLDN16 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,190 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible CLDN16-associated GO terms across cancer lineages are Positive regulation of bicellular tight junction assembly, Response to butyrate, and Response to interleukin-18. Each is linked with CLDN16 in more than 13 cancer types. Because this analysis shows association rather than direction, both CLDN16-to-partner and partner-to-CLDN16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of bicellular tight junction assembly grouped by CLDN16-low versus CLDN16-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN16→partner) and Y-score (partner→CLDN16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Positive regulation of bicellular tight junction assembly →	+0.333	+0.539	<.001	.006	3	14
LARGE_INTESTINE	Response to butyrate →	+0.866	+0.442	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Response to interleukin-18 →	+0.194	+0.847	.003	.001	3	12
CNS	Establishment of skin barrier →	+0.116	+0.210	.001	.008	3	11
BREAST	Negative regulation of interleukin-1 alpha production →	+1.080	+0.578	<.001	.009	3	9
PANCREAS	CD8-positive, alpha-beta T cell activation →	+0.110	+0.759	.001	.004	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,190 associations by consensus.

Positive regulation of bicellular tight junction assembly by CLDN16 expression — LIVER

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