CLDN14

Across TCGA patient cohorts, CLDN14 mutation is significantly associated with the RNA expression of many other genes, with 62 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible CLDN14-associated genes across cancer lineages are MIR933, ARHGAP42P3, and NF1P2. Each is linked with CLDN14 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN14-to-partner and partner-to-CLDN14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR933 grouped by CLDN14-low versus CLDN14-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN14→partner) and Y-score (partner→CLDN14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR933 →	+0.642	+3.788	.001	.009	3	2
BLCA	ARHGAP42P3 →	+0.013	+5.455	<.001	.001	3	2
GBM	NF1P2 →	+0.028	+5.584	<.001	.003	3	1
GBM	P3R3URF-PIK3R3 →	+0.076	+4.969	<.001	.009	3	1
BLCA	MIR3976HG →	+0.165	+5.214	<.001	<.001	3	1
BLCA	LARP7P2 →	+0.269	+3.799	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

MIR933 by CLDN14 expression — BLCA

Explore this box plot interactively →