CLDN14

Across TCGA cell cohorts, CLDN14 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLDN14-associated genes across cancer lineages are GOT1L1, MS4A4A, and BPIFA1. Each is linked with CLDN14 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN14-to-partner and partner-to-CLDN14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GOT1L1 grouped by CLDN14-low versus CLDN14-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN14→partner) and Y-score (partner→CLDN14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GOT1L1 →	+0.080	+6.569	<.001	<.001	3	1
LARGE_INTESTINE	MS4A4A →	+0.242	+3.678	<.001	.009	3	1
LARGE_INTESTINE	BPIFA1 →	+0.157	+4.688	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

GOT1L1 by CLDN14 expression — BLOOD_Leukemia

Explore this box plot interactively →