CLDN12

Across TCGA patient cohorts, CLDN12 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,687 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CLDN12-associated proteins across cancer lineages are VPS50, ZKSCAN1, and SEPTIN6. Each is linked with CLDN12 in more than 5 cancer types. Because this analysis shows association rather than direction, both CLDN12-to-partner and partner-to-CLDN12 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLDN12 versus VPS50 in HNSC, with a Pearson correlation of 0.36.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN12→partner) and Y-score (partner→CLDN12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	VPS50 →	+0.168	+0.450	<.001	<.001	3	6
HNSC	ZKSCAN1 →	+0.354	+0.463	<.001	<.001	3	5
LSCC	SEPTIN6 →	-0.378	-0.492	<.001	<.001	3	5
GBM	WASL →	+0.288	+0.596	<.001	<.001	3	5
BRCA	CD247 →	-0.751	-0.586	.001	.002	3	5
HNSC	CD3E →	-0.935	-0.752	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,687 associations by consensus.

CLDN12 vs VPS50 — HNSC

Explore this scatter interactively →