CLDN12

Across TCGA patient cohorts, CLDN12 protein abundance is significantly associated with the RNA expression of many other genes, with 2,288 significant associations in total. OV shows the largest number of these associations.

The most reproducible CLDN12-associated genes across cancer lineages are EPS8L1, MYOC, and PITPNC1. Each is linked with CLDN12 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN12-to-partner and partner-to-CLDN12 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLDN12 versus EPS8L1 in CCRCC, with a Pearson correlation of 0.60.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN12→partner) and Y-score (partner→CLDN12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	EPS8L1 →	+1.251	+0.433	.008	.003	3	2
CCRCC	MYOC →	-2.030	-0.501	.005	.006	3	2
COAD	PITPNC1 →	+0.536	+0.248	<.001	.001	3	2
UCEC	NAALADL1 →	-0.879	-0.497	.001	.004	3	2
BRCA	PLGLB1 →	-0.321	-0.471	.004	.003	3	2
OV	GAPDHP44 →	+1.076	+0.368	.005	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,288 associations by consensus.

CLDN12 vs EPS8L1 — CCRCC

Explore this scatter interactively →