CLDN12

Across TCGA cell cohorts, CLDN12 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible CLDN12-associated genes across cancer lineages are VCY1B, DEFB125, and OR2B3. Each is linked with CLDN12 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN12-to-partner and partner-to-CLDN12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VCY1B grouped by CLDN12-low versus CLDN12-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN12→partner) and Y-score (partner→CLDN12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	VCY1B →	+1.590	+4.421	<.001	.004	3	1
BREAST	DEFB125 →	+0.036	+5.312	<.001	<.001	3	1
BREAST	OR2B3 →	+0.015	+4.781	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

VCY1B by CLDN12 expression — BREAST

Explore this box plot interactively →