CLDN11

Across TCGA patient cohorts, CLDN11 mutation is significantly associated with the RNA expression of many other genes, with 889 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLDN11-associated genes across cancer lineages are OR2F1, MIR3621, and RNU6-1029P. Each is linked with CLDN11 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN11-to-partner and partner-to-CLDN11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2F1 grouped by CLDN11-low versus CLDN11-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN11→partner) and Y-score (partner→CLDN11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR2F1 →	+0.015	+4.678	<.001	.003	3	2
UCEC	MIR3621 →	+0.281	+2.455	<.001	.003	3	2
CESC	RNU6-1029P →	+0.373	+4.539	<.001	.008	3	1
CESC	POLR2DP1 →	+0.091	+4.669	<.001	.007	3	1
CESC	LINC01517 →	+0.038	+5.269	<.001	.001	3	1
CESC	LINC02559 →	+1.025	+5.342	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 889 associations by consensus.

OR2F1 by CLDN11 expression — SKCM

Explore this box plot interactively →