CLDN11

Across TCGA patient cohorts, CLDN11 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLDN11-associated genes across cancer lineages are A-Raf_pS299, GATA6, and GSK-3a-b_pS21_S9. Each is linked with CLDN11 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN11-to-partner and partner-to-CLDN11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by CLDN11-low versus CLDN11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN11→partner) and Y-score (partner→CLDN11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.180	-3.459	<.001	.005	3	1
UCEC	GATA6 →	-0.174	-1.693	.007	.044	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.396	+1.874	.028	.049	3	1
UCEC	Heregulin →	-0.165	-2.584	.001	.010	3	1
UCEC	INPP4B →	-0.288	-2.000	.035	.030	3	1
UCEC	JNK2 →	+0.270	+1.700	.001	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

A-Raf_pS299 by CLDN11 expression — UCEC

Explore this box plot interactively →