CLDN11

Across TCGA cell cohorts, CLDN11 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CLDN11-associated genes across cancer lineages are SI, LCE3D, and OR4F6. Each is linked with CLDN11 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN11-to-partner and partner-to-CLDN11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SI grouped by CLDN11-low versus CLDN11-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN11→partner) and Y-score (partner→CLDN11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SI →	+0.006	+4.977	<.001	.007	3	1
BLOOD_Leukemia	LCE3D →	+0.061	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR4F6 →	+0.018	+4.922	<.001	.009	3	1
BLOOD_Leukemia	GALP →	+0.027	+5.201	.005	.006	3	1
BLOOD_Leukemia	TCP10L3 →	+0.079	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

SI by CLDN11 expression — SKIN

Explore this box plot interactively →