CLDN1

Across TCGA patient cohorts, CLDN1 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,658 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CLDN1-associated proteins across cancer lineages are EGFR, IL1RAP_S557, and FOSL2. Each is linked with CLDN1 in more than 5 cancer types. Because this analysis shows association rather than direction, both CLDN1-to-partner and partner-to-CLDN1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLDN1 versus EGFR in BRCA, with a Pearson correlation of 0.60.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN1→partner) and Y-score (partner→CLDN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EGFR →	+0.686	+1.587	<.001	<.001	3	5
LSCC	IL1RAP_S557 →	+0.870	+1.633	<.001	.001	3	5
GBM	FOSL2 →	+0.582	+0.869	<.001	.002	3	5
OV	PPL →	+1.050	+1.593	<.001	.001	2	6
BRCA	PPL_S887 →	+1.434	+1.962	<.001	.001	3	5
PDAC	KRT5 →	+1.882	+0.984	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,658 associations by consensus.

CLDN1 vs EGFR — BRCA

Explore this scatter interactively →