CLDN1

Across TCGA patient cohorts, CLDN1 protein abundance is significantly associated with the RNA expression of many other genes, with 4,658 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible CLDN1-associated genes across cancer lineages are CLDN16, CUBN, and KRT5. Each is linked with CLDN1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CLDN1-to-partner and partner-to-CLDN1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLDN1 versus CLDN16 in OV, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN1→partner) and Y-score (partner→CLDN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CLDN16 →	+3.055	+0.713	<.001	<.001	3	4
CCRCC	CUBN →	-2.972	-0.927	.001	.008	3	3
LSCC	KRT5 →	+3.032	+1.046	<.001	<.001	3	3
HNSC	DLG1-AS1 →	+0.687	+0.944	<.001	<.001	3	3
PDAC	ATP8A1 →	-0.896	-0.576	<.001	.003	3	3
LUAD	EBF1 →	-0.764	-1.201	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,658 associations by consensus.

CLDN1 vs CLDN16 — OV

Explore this scatter interactively →