CLDN1

Across TCGA patient cohorts, CLDN1 mutation is significantly associated with the RNA expression of many other genes, with 1,929 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLDN1-associated genes across cancer lineages are CHEK1, EIF4E, and RAD17. Each is linked with CLDN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN1-to-partner and partner-to-CLDN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHEK1 grouped by CLDN1-low versus CLDN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN1→partner) and Y-score (partner→CLDN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHEK1 →	+0.639	+3.606	<.001	.001	3	2
UCEC	EIF4E →	+0.381	+3.606	.005	.001	3	2
UCEC	RAD17 →	+0.450	+2.321	.001	.001	3	2
UCEC	CWC27 →	+0.469	+3.765	.002	<.001	3	2
SKCM	ZUP1 →	+0.507	+3.710	.007	<.001	3	2
SKCM	NUS1 →	+0.580	+2.604	.008	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,929 associations by consensus.

CHEK1 by CLDN1 expression — UCEC

Explore this box plot interactively →