CLDN1

Across TCGA patient cohorts, CLDN1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLDN1-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and eIF4G. Each is linked with CLDN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN1-to-partner and partner-to-CLDN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CLDN1-low versus CLDN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN1→partner) and Y-score (partner→CLDN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.267	-2.415	.008	.003	3	1
UCEC	eIF4E →	+0.202	+3.183	.017	.009	3	1
UCEC	eIF4G →	+0.296	+1.906	.017	.016	3	1
UCEC	A-Raf_pS299 →	-0.159	-2.321	<.001	.034	3	1
UCEC	ERK2 →	+0.234	+1.906	.002	.016	3	1
UCEC	FOXO3a_pS318_S321 →	-0.129	-1.690	.010	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

EGFR_pY1068 by CLDN1 expression — UCEC

Explore this box plot interactively →