CLDN1

Across TCGA cell cohorts, CLDN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,034 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CLDN1-associated GO terms across cancer lineages are Response to interleukin-18, Positive regulation of epithelial cell proliferation involved in wound healing, and Response to butyrate. Each is linked with CLDN1 in more than 14 cancer types. Because this analysis shows association rather than direction, both CLDN1-to-partner and partner-to-CLDN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to interleukin-18 grouped by CLDN1-low versus CLDN1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN1→partner) and Y-score (partner→CLDN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Response to interleukin-18 →	+0.347	+4.219	<.001	<.001	3	15
URINARY_TRACT	Positive regulation of epithelial cell proliferation involved in wound healing →	+1.748	+4.330	<.001	<.001	3	14
BREAST	Response to butyrate →	+0.981	+3.474	<.001	<.001	3	14
LIVER	Positive regulation of bicellular tight junction assembly →	+0.333	+4.540	<.001	<.001	3	12
BONE	Negative regulation of interleukin-1 alpha production →	+1.310	+3.391	<.001	<.001	3	12
SOFT_TISSUE	Establishment of skin barrier →	+0.217	+3.206	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,034 associations by consensus.

Response to interleukin-18 by CLDN1 expression — BONE

Explore this box plot interactively →