CLDN1

Across TCGA cell cohorts, CLDN1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CLDN1-associated genes across cancer lineages are GSG1L2, IFNA4, and LMX1A. Each is linked with CLDN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLDN1-to-partner and partner-to-CLDN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSG1L2 grouped by CLDN1-low versus CLDN1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLDN1→partner) and Y-score (partner→CLDN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GSG1L2 →	+0.043	+4.969	<.001	.003	3	2
CNS	IFNA4 →	+0.215	+5.321	<.001	.005	3	1
BLOOD_Leukemia	LMX1A →	+0.172	+4.409	<.001	.005	3	1
BLOOD_Leukemia	TMEM196 →	+0.053	+4.874	<.001	.002	3	1
BLOOD_Leukemia	PRAMEF7 →	+0.009	+4.539	.008	.007	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

GSG1L2 by CLDN1 expression — BLOOD_Leukemia

Explore this box plot interactively →