Across TCGA patient cohorts, CLCNKB mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLCNKB-associated genes across cancer lineages are MEK1, mTOR_pS2448, and PCNA. Each is linked with CLCNKB in more than 1 cancer types. Because this analysis shows association rather than direction, both CLCNKB-to-partner and partner-to-CLCNKB results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLCNKB→partner) and Y-score (partner→CLCNKB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.448	+2.906	.001	.001	3	2
UCEC	mTOR_pS2448 →	-0.152	-3.565	.009	.002	3	2
UCEC	PCNA →	+0.200	+2.000	.018	.010	3	2
UCEC	4E-BP1_pT37_T46 →	-0.496	-3.571	<.001	.002	3	2
UCEC	A-Raf_pS299 →	-0.137	-2.700	.003	.006	3	1
UCEC	ERK2 →	+0.270	+2.502	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration

CLCNKB survival (RNA) · tumor vs normal (RNA) · all CLCNKB data types